Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization
نویسندگان
چکیده
منابع مشابه
Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization
To identify pathways involved in adult lung regeneration, we employ a unilateral pneumonectomy (PNX) model that promotes regenerative alveolarization in the remaining intact lung. We show that PNX stimulates pulmonary capillary endothelial cells (PCECs) to produce angiocrine growth factors that induce proliferation of epithelial progenitor cells supporting alveologenesis. Endothelial cells trig...
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ژورنال
عنوان ژورنال: Cell
سال: 2011
ISSN: 0092-8674
DOI: 10.1016/j.cell.2011.10.003